Andy Murray was knocked out of the US Open at the hands of Kei Nishikori in an enthralling quarterfinal match at Flushing Meadows on Wednesday.

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The Japanese, who lost out to Murray in the Olympic semifinals last month, recovered from a worrying start to come away with a 1-6, 6-4, 4-6, 6-1, 7-5 victory.

Read:>Murray rues serving display in US Open loss

Also read:>'Tough' Nishikori grateful for rain delay

After struggling to cope with Murray's strong returning in the opening set, Nishikori battled back after a rain delay to stun the World No. 2. The result marks just a second victory for the 2014 finalist over Murray in nine attempts.

A long backhand from Nishikori earned Murray his first break to go 3-1 up, and the Briton's vicious return of serve saw him power to a swift first-set victory. Murray's dominance of the opening set faded in the second and, although he made the first break, Nishikori immediately pegged him back in a pattern that would later become a recurring theme.

After a pause for the roof to be closed, Nishikori levelled matters as Murray found the net following a long rally. Nishikori appeared to have the crowd on his side against a visibly frustrated Murray. The Japanese twice came up with an immediate response to Murray breaks during a tight third set, but the Olympic Champion made a third gain stick and held serve to go back in front.

Having started with a dominant 6-1 victory, Murray's match was flipped on its head when Nishikori claimed the fourth by the same scoreline as part of a seven-game winning run. Murray finally stemmed the tide by holding serve to pull back to 2-1 in the decider and he converted a second break point to pull level.

It proved to be brief respite for Murray, though, as Nishikori fired a winner down the left to regain the advantage, but a match of twists and turns had another twist — and turn — to come.

Murray's break to level at 4-4 had the feel of a moment that could shift the momentum in his favour, yet Nishikori — chasing just a second grand slam semifinal appearance — would come again.

A double fault from Murray handed Nishikori a break point that was duly converted to the fury of the Wimbledon Champion, and the 26-year-old held serve to wrap up a memorable win.

STATISTICAL BREAKDOWN
Nishikori [6] bt Murray [2] 1-6 6-4 4-6 6-1 7-5

WINNERS/UNFORCED ERRORS 
Nishikori - 48/60
Murray - 29/46

ACES 
Nishikori - 1
Murray - 8

BREAK POINTS WON  
Nishikori - 9/13
Murray - 8/15

FIRST SERVE PERCENTAGE  
Nishikori - 60
Murray - 55

PERCENTAGE OF POINTS WON ON FIRST/SECOND SERVE 
Nishikori - 72/43
Murray - 69/39

TOTAL POINTS  
Nishikori - 142
Murray - 130