Bayer Leverkusen slumped to a 3-0 defeat at home to Hoffenheim after playing virtually the entire match with 10 men. Kevin Volland earned the fastest red card of the season with just six minutes gone for bringing down Kerem Demirbay, who was through on goal.
Demirbay then put Hoffenheim ahead on 15 minutes and ex-Bayern forward Sandro Wagner was left to roam free in the area as he slotted home on 49 minutes.
Bayer coach Roger Schmidt was sent to the stands for arguing with the referee in the wake of the second goal before Swiss midfielder Steven Zuber netted the visitors' third.
Whereas in another encounter, Ten-man Wolfsburg dropped to 15th after its 3-1 defeat at Darmstadt which left them seven games without a win. Frenchman Valerien Ismael was appointed Wolfsburg's new head coach on Monday after Dieter Hecking was sacked.
His new charges were reduced to 10 men midway through the first half when Dutch defender Jeffrey Bruma was sent off for bringing down Laszlo Kleinheisler, who was through on goal, and Tunisia international Anis Ben-Hatira drilled home the resulting free-kick.
Germany striker Mario Gomez scored his first goal for Wolfsburg when he headed home a Julian Draxler corner on the hour.
Darmstadt regained the lead eight minutes later when Hungary international Kleinheisler slotted home before Sandro Sirigu added third for his team.
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