Cristiano Ronaldo rarely goes five games without scoring but he heads into Juventus' clash with Manchester United seeking his first Champions League goal in six outings.
He is not the only one hoping to end an unwanted streak, as AEK Athens travels to Bayern Munich aiming for a first away victory in 24 matches in Europe's premier club competition.
With Roma playing away at CSKA Moscow and Real Madrid travelling to Viktoria Plzen, Wednesday's fixtures could deliver some surprises. Our Opta-powered preview gives the lowdown on the key numbers for each contest.
Benfica vs Ajax
5 - Ajax has not lost any of its last five competitive games against Benfica, picking up a draw and four wins including its 1-0 victory at Johan Cruijff Arena in October.
4 - Benfica has picked up just four points in its last 11 Champions League group matches, and has lost all of its last four home games in the competition.
Bayern Munich vs AEK Athens
10 - The German champion relishes matches against Greek opposition, having not lost in all 10 competitive encounters, scoring 18 without reply in its last five home matches against Super League sides.
23 - AEK is aiming to end a streak of 23 winless away matches in the European Cup/Champions League, leaving it over half way to matching Olympiacos' record sequence of 45 games between 1959 and 2006.
Lyon vs Hoffenheim
6 - Lyon is proving harder to beat in the Champions League than it has been in over a decade after going undefeated in their last six outings - its best run since going seven without loss between September 2006 and February 2007.
5 - In contrast, Hoffenheim is winless in its last five European away matches following two draws and three defeats, including qualifiers.
Manchester City vs Shakhtar Donetsk
4 - Defeat for City would see it become the first English side to lose four consecutive home matches in the history of the European Cup/Champions League.
24 - City managed 24 shots in its 3-0 win over Shakhtar last time out, which was the most the Ukrainian side had faced in a Champions League match since Real Madrid hit 26 against them in September 2015.
CSKA Moscow vs Roma
23 - The average age of CSKA's starting line-up in its 3-0 defeat at Roma in October was just 23 years and 92 days - the youngest in the Champions League since November 2014 (Ajax vs PSG, 22y 305d).
10 - Edin Dzeko is the Champions League's top scorer in 2018, finding the net 10 times - two more than any other player.
Viktoria Plzen vs Real Madrid
9 - In the nine matches between Czech and Spanish clubs in the Champions League, La Liga sides have emerged victorious in all of them, scoring at least two goals per game.
8 - Gareth Bale is in good form in the Champions League and has been involved in eight goals in his last seven group-stage appearances (four goals, four assists).
Valencia vs Young Boys
6 - After losing four and drawing two of its last six matches Valencia is on its worst winless streak in the Champions League since October 2011, when it also went six games without a victory.
42 - Valencia and Young Boys have had 42 shots each in this season's Champions League, and both sides have scored just once.
Juventus vs Manchester United
5 - Cristiano Ronaldo has failed to score in his last five Champions League outings, his last goal coming for Real Madrid against Juventus in April.
2 - Along with Bayern Munich, Manchester United is one of two sides to have won two away Champions League matches at Juventus - no side has won more.
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