The Champions League action has Juventus bidding to improve its chances of reaching the last 16, along with Paris Saint-Germain, Bayern Munich and Barcelona on Wednesday.
CSKA Moscow hosts Basel and Manchester United is visiting Benfica, while Atletico Madrid is look to end a miserable away run in the competition.
In Group C, Chelsea faces Roma in a crunch clash as Antonio Conte's men aim to build on fine European form after domestic struggles.
Click on the Match Centre to catch all the updates from your favourite fixtures...
CSKA Moscow vs Basel ( Match Centre )
30 - CSKA has failed to keep a clean sheet in its last 30 Champions League games, its last shut-out coming in November 2011 against Trabzonspor (0-0). In fact, Igor Akinfeev has failed to keep a clean sheet in his last 41 games (excluding qualifiers), the longest ever run for a goalkeeper in the competition.
5 - Basel's 5-0 success against Benfica on the last match day was the Swiss team's biggest win in the Champions League. It has won consecutive games only once before in the competition, back in 2011-12.
Benfica vs Manchester United ( Match Centre )
1 - Benfica has won only one of its nine games against Manchester United in all competitions (D2 L6), a 2-1 home win in the 2005-06 Champions League group stages.
3 - United has scored more headed goals than any other team in this season's Champions League (3).
Anderlecht vs Paris Saint-Germain ( Match Centre)
4 - Anderlecht and PSG's last encounter in Belgium produced a 5-0 win for the French side in October 2013, including a four-goal performance by Zlatan Ibrahimovic. It's still PSG's joint-largest away win and Anderlecht's joint-largest home defeat in European competition.
11 - Edinson Cavani has scored 11 goals in 10 Champions League games since last season. He’s the fifth player to score in six consecutive games in the competition after Ruud van Nistelrooy, Marouane Chamakh, Burak Yilmaz and Cristiano Ronaldo
Bayern Munich vs Celtic ( Match Centre )
26 - Away from home in the Champions League, Celtic has lost 26 of its 31 games (W2 D3). However, it won 3-0 at Anderlecht on its last outing, keeping the first ever clean sheet away from home in the competition.
100 - If Arjen Robben plays , it will be his 100th game in the Champions League. He would become only the second Dutch player to reach that landmark after Clarence Seedorf (125 games in total).
Qarabag vs Atletico Madrid ( Match Centre )
7 - Qarabag's 7-goal difference (one for, eight against) is the worst so far in this season's Champions League. It also had fewer shots on target than any team so far (three in two games).
0 - Atletico Madrid is winless in its last three Champions League away games (D2 L1). It has never gone four in a row without a win away from home under Diego Simeone.
Chelsea vs Roma ( Match Centre )
2 - Chelsea has picked up maximum points from its opening two games of a Champions League campaign for the first time since 2010-11. It has always finished top of its group after winning two opening games.
3 - Unbeaten so far (W1 D1), Roma is attempting to go through its first three games of a Champions League campaign without a defeat for the first time ever.
Juventus vs Sporting CP ( Match Centre )
20 - Juventus is unbeaten in its last 20 Champions League home games (W13 D7), its longest ever run without a defeat in the competition on home soil. Bayern Munich is the last team to beat the Italian bunch, back in April 2013 (2-0).
1 - Sporting has already won more away games this season (1) than it did over its previous two Champions League campaigns (0).
Barcelona vs Olympiakos ( Match Centre )
6 - Barcelona has won all six of its home games against Greek clubs in all competitions, scoring 26 goals and conceding only three.
6 - Ernesto Valverde took charge of six Champions League matches with Olympiacos in the 2011-12 group stages, winning three and losing three.