Eden Hazard must wait to make his Real Madrid comeback after failing to make the matchday squad for the Copa del Rey clash with Real Sociedad, while Gareth Bale is missing once again.
Belgium forward Hazard has been absent since November with an ankle injury and only returned to training last week.
There had been hope he could feature in the derby against Atletico Madrid, which Zidane's men won 1-0 on Saturday, but he was not included for that game.
Head coach Zinedine Zidane was non-committal on his involvement for the quarterfinal tie against Sociedad and Hazard was not among a 19-man squad named on Wednesday.
Bale remains conspicuous by his absence after Zidane said his exclusion for the match against Atleti was not due to injury, saying: "He was available. When it came to deciding, I picked others."
Casemiro, Lucas Vazquez and Dani Carvajal are also not among those selected. Reports in Spain suggest Casemiro has been suffering with flu, while Carvajal took a knock against Atleti. Nacho Fernandez, Brahim Diaz and Rodrygo Goes – all absent against Atleti – are included against Sociedad.