Cesc Fabregas's goal earned Chelsea a 1-0 victory at Sunderland on Wednesday — its 10th in succession — as Antonio Conte's side surged six points clear at the Premier League summit.
Fabregas, who came in for Nemanja Matic, curled in from Willian's 40th-minute cut-back to establish Chelsea's longest winning run within the same league campaign since 2005-06.
"Today we didn't pay, but when you have the possibility to kill the game, you must kill the game," said Chelsea manager Conte.
"I prefer my players not to look at the table and to focus on the next game in three days (at Crystal Palace). We must prepare very well to have a good Christmas."
There were also wins for Liverpool, Manchester City and Tottenham Hotspur, while Zlatan Ibrahimovic's 88th-minute strike earned Manchester United a 2-1 win at Crystal Palace.
Chelsea, for whom Eden Hazard missed out due to a knock, has won all 10 league games it has played since losing 3-0 at Arsenal on September 24, keeping eight clean sheets.
But it took a flying save from goalkeeper Thibaut Courtois to prevent Patrick van Aanholt snatching a point for bottom club Sunderland at the death.
Conte's men are six points clear of Liverpool, who stole above Arsenal into second place courtesy of a 3-0 win at Middlesbrough in which Adam Lallana scored twice.
Having seen his side beaten 4-3 at Bournemouth and then held to a 2-2 draw by West Ham United, Liverpool manager Jurgen Klopp dropped goalkeeper Lorus Karius for Simon Mignolet.
His team went ahead in the 29th minute when Lallana headed in from England team-mate Nathaniel Clyne's right-wing cross.
Lallana teed up Divock Origi to add a second on the hour and eight minutes later the Belgian returned the favour as Lallana claimed his second goal.
"About a year ago I had sat him in the office and I was happy with him, but he was like, 'I'm not scoring,'" Klopp said of Lallana.
"And I said he wasn't in the right positions. Tonight he was twice in the right position and it was wonderful."
Liverpool moved above Arsenal on goal difference, Arsene Wenger's side having lost 2-1 at Everton on Tuesday.
In further bad news for Arsenal, City, Tottenham and United all closed in on them.
Rondon's headed hat-trick
Pep Guardiola's City hit back after successive defeats against Chelsea and champion Leicester City by winning 2-0 at home to Watford.
Guardiola, who dropped John Stones and reverted to a back four, saw his side prevail thanks to goals in each half by Pablo Zabaleta and David Silva.
"We won, we had a good performance," said Guardiola. "All the team worked hard and it is good to get a clean sheet."
The only black mark for City was a knee injury sustained by Ilkay Gundogan, which Guardiola said was likely to keep the Germany midfielder out for "several months".
City remains fourth, seven points adrift of Chelsea, but only a point below Liverpool and Arsenal.
Tottenham is three points back in fifth place after Christian Eriksen scored twice in a 3-0 home win over Hull City, with Victor Wanyama also on target.
Having beaten Spurs 1-0 on Sunday, United recorded back-to-back league wins for the first time since August by edging Palace to remain three points below Mauricio Pochettino's men in sixth place.
Jose Mourinho's side went ahead in first-half stoppage time at Selhurst Park when Ibrahimovic chested down Juan Mata's free-kick for Paul Pogba to score from close range.
United were pegged back in the 66th minute when James McArthur beat David de Gea at his near post, but with full-time beckoning Pogba freed Ibrahimovic to dink home his 14th goal of the season.
"It was very difficult, but very deserved," Mourinho told the BBC.
"It was an amazing reaction and I am really pleased for the players."
West Bromwich Albion climbed to the heady heights of seventh place after a hat-trick of headers by Salomon Rondon gave Tony Pulis's men a 3-1 home win over third-bottom Swansea City.
The Venezuelan striker became the first player to score a headed Premier League hat-trick since Everton's Duncan Ferguson in December 1997. Wayne Routledge replied for Swansea.
West Ham pulled clear of the relegation zone after Mark Noble tucked away the rebound from his own penalty to secure a 1-0 home win over Burnley.
Stoke City survived the 22nd-minute dismissal of Marko Arnautovic for a studs-up lunge at Sofiane Boufal to secure a 0-0 draw at home to Southampton.
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