Europa League favourites Arsenal and Atletico Madrid have been kept apart in the quarter-finals, having been drawn against CSKA Moscow and Sporting CP respectively.
Arsene Wenger's side thrashed AC Milan 5-1 on aggregate in the last 16, sending out a real statement to all those left in the competition.
Atletico enjoyed a similarly straightforward passage, with their 5-1 second-leg win away at Lokomotiv Moscow wrapping up an emphatic 8-1 triumph.
Both sides will expect tough ties, particularly given the lengthy journey to Moscow facing Arsenal, but they and Atletico will still be expected to progress.
RB Leipzig are enjoying a strong showing in their maiden season in European football and will come up against stalwarts Marseille, who beat Athletic Bilbao 5-2 over two legs.
And Borussia Dortmund's conquerors Red Bull Salzburg will take on Lazio, who could be considered dark horses given their position of fourth in Serie A.
The first-leg matches will take place on April 5, with the return games scheduled for a week later.
Draw in full:
RB Leipzig v Marseille
Arsenal v CSKA Moscow
Atletico Madrid v Sporting CP
Lazio v Red Bull Salzburg
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