Manchester United will face trips to Kazakhstan and Serbia in the Europa League, while 2018-19 runner up Arsenal was grouped with last season's semifinalist Eintracht Frankfurt.
United, Europa League winner in 2016-17, was placed in Group L in Friday's draw and will take on Astana, Partizan Belgrade and AZ.
Though a long trip to Kazakhstan for the Astana clash is far from preferable and Belgrade will prove a difficult place to visit, Ole Gunnar Solskjaer's side will be clear favourite to progress.
Arsenal was drawn in Group F, with Bundesliga side Frankfurt likely to present the biggest challenge to the Gunners, who must also take on Standard Liege and Vitoria Guimaraes.
Fellow Premier League club Wolves, making its first appearance in a major European competition since 1980-81, was handed encounters against Besiktas, Braga and Slovan Bratislava in Group K.
Five-time winner Sevilla should progress comfortably from Group A, which also includes APOEL, Qarabag and Dudelange.
Celtic was knocked out of Champions League qualification by Cluj and Neil Lennon's side will meet it once again in a tough Group E, where Lazio and Coupe de France holder Rennes joins them.
Rangers were also dealt a difficult hand, with Porto, Feyenoord and Young Boys their opponents in Group G. Meanwhile, Group B has thrown up a derby between Sweden's Malmo and Copenhagen of Denmark.
Comments
SHARE