Harry Kane netted his 200th goal for Tottenham Hotspur as it won 3-1 at Ludogorets and AC Milan's 24-match unbeaten run ended with a 3-0 loss to Lille in the Europa League on Thursday.
England striker Kane headed home Lucas Moura's corner to set Spurs on course for a victory over the Bulgarians that put them top of Group J on goal difference with six points from three games after Royal Antwerp lost 1-0 to Austrian side LASK.
AC Milan's superb run in all competitions came to a shuddering halt as Lille's Turkish winger Yusuf Yazici opened the scoring with a penalty and added two second-half goals in a comprehensive win that put the French side top of Group H.
Yazici's second hat-trick in three Europa League group games put Lille on seven points, one ahead of Milan. Sparta Prague is third after its 4-1 drubbing of Celtic in Glasgow.
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England's Leicester City took control of Group G with its third win in three games, thrashing second-placed Braga 4-0, while AEK Athens beat FC Zorya of Ukraine 4-1 to stay third.
Arsenal also notched a third successive win, 4-1 over Molde, helped by two own goals from the Norwegians. The London side leads Group B on nine points, three ahead of Molde and six clear of Rapid Vienna which beat bottom side Dundalk 4-3.
In Greece, PAOK bounced back from a goal down with four second-half strikes to defeat Dutch side PSV Eindhoven 4-1 and go second in the table on five points, two behind Granada, which won 2-0 at bottom side Omonia Nicosia.
AS Roma put in its most impressive performance of the Group A campaign with a 5-0 drubbing of Romania's CFR Cluj, Borja Mayoral netting twice for the Italians. It tops Group A ahead of Swiss side Young Boys which downed CSKA Sofia 3-0.
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A stoppage-time goal by Darwin Nunez snatched a 3-3 draw for 10-man Benfica at home to Scottish side Rangers in Group D. Rangers leads the group on goal difference from Benfica.
There were goals galore in Group C with leader Slavia Prague beating French side Nice 3-2 while second-placed Bayer Leverkusen came back from a goal down to win 4-2 at bottom side Hapoel Beer Sheva.
Group F remains tight with AZ Alkmaar top on goal difference despite losing 1-0 to Real Sociedad. Alkmaar, Sociedad and Italian side Napoli, which won 2-1 at Rijeka, all have six points.
Villarreal's home clash with Maccabi Tel Aviv was delayed by over an hour due to torrential rain which left the pitch waterlogged.
Now not the time to think about records: Kane
Kane's 200th goal made him only the third Spurs player to reach the milestone and the 27-year-old is eight goals behind Bobby Smith and could threaten Jimmy Greaves's record of 266.
"These are great things but hard to take in while you're playing," Kane told the club's website. "Once you finish your career you take it all in."
Kane's first goal for the club was also in Europe's second-tier club competition, a neat finish late in the game against Shamrock Rovers in 2011.
"Time goes so quickly and it feels like yesterday that I scored that first goal," he added. "It's a great achievement to reach 200 and hopefully there's a few more left. Let's keep them coming."
Spurs manager Jose Mourinho said Kane could go on and replace Greaves as Spurs record scorer.
"What he's achieving in the Premier League and all competitions is great for such a young guy," Mourinho added. "Can he become the record scorer? I believe he can. It's just a matter of time."