Borussia Dortmund progressed to the next round at the expense of Porto, with Iker Casillas' unfortunate own goal making the difference on Thursday.
>FC Porto 0-1 Borussia Dortmund (Agg 0-3)
Spanish Armada rolls on
Villarreal made it through at the expense of Napoli as Tomas Pina cancelled out Marek Hamsik's opener for a 1-1 draw after its 1-0 first-leg win, while defending champion Sevilla reached the last 16 despite its 1-0 loss against Molde.
Second-half goals from Rodrigo, Sofiane Feghouli, Pablo Piatti and Ruben Vezo helped Valencia to a 4-0 away win over Rapid Wien, making it 10-0 on aggregate for Gary Neville's men.
Sabin Merino's second-half goal helped Athletic Bilbao to a 1-1 draw against Marseille, which proved just enough after last week's 1-0 away win.
>Napoli 1-1 Villareal (Agg 1-2)
>Rapid Wien 0-4 Valencia (Agg 0-10)>
>Athletic Bilbao 1-1 Marseille (Agg 2-1)
Basel shocked Saint-Etienne 2-1 (4-4 agg) to go through, with Luca Zuffi the hero following his last-minute winner, while Shakhtar Donetsk beat Schalke 3-0 in Gelsenkirchen to progress, with Marlos, Facundo Ferreyra and Viktor Kovalenko finding the net.
>FC Basel 2-1 St Etienne (Agg 4-4, Basel win on away goals)
>FC Schalke 0-3 Shakhtar Donetsk (Agg 0-3)
A fine second-half performance saw Lazio record a 3-1 victory over Galatasaray to progress, with Marco Parolo, Felipe Anderson and Miroslav Klose among the goalscorers for the Serie A side.
Bayer Leverkusen saw off Sporting CP 3-1 at the BayArena, with Karim Bellarabi putting in a man of the match performance to lead the way for his side.
>Lazio 3-1 Galatasaray (Agg 4-2)
>Bayer Leverkusen 3-1 Sporting Lisbon (Agg 4-1)
Anderlecht needed extra time to end Olympiacos' European dreams, with Franck Acheampong netting twice in extra time to make it 2-1 on the evening and 3-1 on aggregate.
Fenerbahce recorded a 1-1 draw with Lokomotiv Moscow to book its ticket for the next round after last week's 2-0 victory, while Sparta Prague saw off Krasnodar 3-0 to qualify.
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