Luis Suarez is bidding to end a miserable run in away Champions League matches as Barcelona travels to play Slavia Prague in one of eight games on Wednesday.
Barca earned an important win over Inter on matchday two but still have work to do to progress from a competitive Group F that also contains Borussia Dortmund, which faces Antonio Conte's side this time around.
Chelsea travels to play Group H pace-setters Ajax in Amsterdam, having got its campaign back on track with a win against Lille last time out.
Liverpool trails Napoli in Group E but will be confident of defeating Genk after edging a thrilling contest against Salzburg 4-3 at Anfield three weeks ago.
Below, we have highlighted the key data ahead of Wednesday's contests.
RB Leipzig v Zenit7 - RB Leipzig's last seven Champions League results have alternated between a win and a defeat. It lost its last match 2-0 at home to Lyon.
10 - Zenit is winless in its last 10 away European matches (including qualifiers), drawing three and losing seven since beating Real Sociedad 3-1 in a Europa League match back in December 2017.
Ajax v Chelsea
5 - If he scores against Chelsea, Quincy Promes will become the fifth Dutchman in the history of the European Cup/Champions League to score in three consecutive appearances for Ajax. The others are Johan Cruyff (April 1969), Ruud Geels (November 1977), Ruud Krol (October 1979) and Patrick Kluivert (October 1995).
8 - Since losing 3-0 at Barcelona in March 2018, Chelsea has lost none of its eight away European matches (W6 D2 L0), its longest ever unbeaten away run on the continent.
Salzburg v Napoli
0 - This is the first Champions League encounter between an Austrian team and an Italian side since December 2005, when Juventus won 3-1 away at Rapid Vienna. A team from Austria have never beaten an Italian outfit in the Champions League (W0 D1 L7).
19 – Including qualifiers, Salzburg has not lost any of its last 19 home European matches (W15 D4 L0), winning the last six in a row.
Genk v Liverpool
14 - Should Genk fail to defeat Liverpool, it will set a record for games played in the European Cup/Champions League without winning. It has played 14 so far (W0 D8 L6), level with Floriana and Shamrock Rovers.
1 – Liverpool has won only one of its last 10 away Champions League group-stage matches (W1 D3 L6), losing each of the last four in a row.
Benfica v Lyon
10 - No French side has ever won an away European match against Benfica in 14 attempts (W0 D4 L10), with 10 different teams failing to win.
2 – Lyon is looking to win consecutive away Champions League matches in the same campaign for the first time since 2009, when they beat Debreceni and Liverpool.
Inter v Borussia Dortmund
6 - Inter is winless in six European matches against German opposition (W0 D1 L5) since a 3-2 win over Bayern Munich in the Champions League in March 2011.
2 – Dortmund has only conceded two goals in its last eight Champions League group stage matches, keeping clean sheets in seven of those matches.
Slavia Prague v Barcelona
4 – This is the first meeting between the two sides in Europe, though Barcelona have won all four of its previous Champions League meetings against Czech opponents.
19 – Suarez scored twice against Inter on MD2 in Barcelona's 2-1 victory, but the Uruguay striker is goalless in his last 19 away Champions League matches, attempting 59 shots without success since a goal against Roma in September 2015.
Lille v Valencia
6 - Lille is yet to defeat a Spanish team in the Champions League in six attempts (W0 D3 L3), facing Deportivo de La Coruna, Villarreal and Valencia previously without success.
11 – Valencia has failed to score in seven of their last 11 Champions League matches. Prior to that run, it had been unable to score in just seven of its previous 33 in the competition.
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