James Anderson has been ruled out of the rest of the Ashes series due to pain in his right calf, the England and Wales Cricket Board has announced.
England’s record Test wicket-taker limped out of the action on day one of the opening match in the series at Edgbaston, and has not been involved since.
However, the 37-year-old seamer clung to the hope he would be able to prove his fitness in time for the matches at Old Trafford and The Oval.
His prospects looked to be improving as he took part in two second XI matches for his county Lancashire, but Anderson suffered a setback on Thursday, and medical checks dealt him bad news.
The ECB said on its website: "England and Lancashire seamer James Anderson has been ruled out for the rest of the Specsavers Ashes series.
"Whilst bowling in the ninth over on Thursday in Lancashire’s second XI four-day friendly against Durham at Chester Boughton Hall Cricket Club, Anderson became aware of right calf pain following on from 20 overs he had bowled on Tuesday.
"He immediately sought a medical assessment from Lancashire and was withdrawn from the remainder of the game. Further review with the ECB medical team has confirmed that he will be unavailable for the remaining two Specsavers Ashes Tests."