Having scored a hat-trick for Argentina in World Cup qualifying, Lionel Messi will have to wait for his home debut in France, possibly leaving Paris Saint-Germain without its star front three for Saturday's Ligue 1 match against promoted side Clermont.
PSG boss Mauricio Pochettino will be deprived of the majority of his South American contingent after their countries played World Cup qualifiers on Thursday.
Messi notched all three goals as Argentina, who also included PSG's Angel Di Maria in its lineup, beat Bolivia 3-0 barely 36 hours before the Parisians are due to kick off at the Parc des Princes.
The triple strike made Messi the top international goalscorer in South American football history with 79 goals, overtaking Pele.
Neymar will also be absent after scoring in Brazil's 2-0 victory against Peru.
"Those players played in the early morning so Leandro Paredes, Lionel Messi and Neymar are not going to be involved with the squad tomorrow, it's common sense," Pochettino told a news conference.
The third member of the attacking trio, Kylian Mbappe, is still an injury doubt after leaving the France camp with a calf injury he suffered in its first qualifier of the international break against Bosnia and Herzegovina.
However, Pochettino believes Mbappe will recover in time for the match against Clermont. "Kylian is happy, he is emotionally stable and before the end of the transfer window he stayed in a positive mindset," said Pochettino.
"He wants to play football and enjoy himself. He has been training and recovering well so we hope he will be involved with the squad."
All three are expected to get ready in time for PSG's Champions League opener at Club Brugge on Wednesday.
The 2020 Champions League runners-up will be judged this season on its performances in the European competition, which they have never won despite the substantial injection of funds from their Qatari owners.
Expectations are even higher than usual after a transfer window in which Messi, Georginio Wijnaldum, Achraf Hakimi and goalkeeper Gianluigi Donnarumma all joined the club.
There could be a debut against Clermont for Portugal full-back Nuno Mendes, the lowest-profile of the summer arrivals.
But the 19-year-old impressed in Sporting Lisbon's title-winning team last term and could prove a bargain after joining PSG on a season-long loan for a reported seven million euros ($8.3 million), with an option to buy for 40 million euros.
"It's a moment of great pride for me to have signed here among all these great players," Nuno Mendes, who has won eight international caps, told PSG's website. "I think it's every player's dream to play alongside them."
"I think it's important for me to stay calm, to do what I do best."
PSG is stronger favourite to win Ligue 1 than ever before -- although Lille wrested the title from it last season -- and its expensively assembled team already sits top after four wins from as many matches.
(Inputs from Reuters)
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