Bayern Munich was hammering Hoffenheim 6-0 when the Bundesliga match was halted in the second half due to insulting chants and banners aimed at Dietmar Hopp.
With Bayern coasting to victory in a dominant display, referee Christian Dingert paused the match as a banner was unfurled in the away end.
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Borussia Dortmund fans were previously banned from matches at Rhein-Neckar-Arena for a similar protest against Hoffenheim owner Hopp, an unpopular figure among some German football fans due to his financing of the club.
Bayern players entered the stands to implore the supporters to remove the banner, with head coach Hansi Flick racing across the pitch to join his team.
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The banner was initially removed and the chanting paused, but the insults resumed and official Dingert directed the players back to the dressing rooms.