Chelsea will face Malmo in the last-32 of the Europa League, while Premier League counterpart Arsenal takes on BATE.
Maurizio Sarri's men and Unai Emery's side both progressed to the knockout stages as group winner so will play their first legs away from home.
Five-time winner Sevilla faces a plum tie against Lazio and four of its former players Luis Alberto, Joaquin Correa, Martin Caceres and Ciro Immobile.
Napoli is among the favourites for the trophy, having missed out at the expense of Paris Saint-Germain and Liverpool in a tightly contested Champions League section, and takes on Zurich.
Serie A counterpart Inter dramatically missed out the last-16 of Europe's premier competition at Tottenham's expense on the final matchday and now faces Rapid Vienna, who is licking its wounds from a 6-1 derby pummelling against neighbour Austria Vienna on Sunday.
Scottish Premiership champions Celtic face a daunting task against Valencia, who drop down from a Champions League group from which Manchester United and Juventus progressed.
Bundesliga side Bayer Leverkusen progressed from Group A as winner and a long trip to Krasnodar is its reward.
Other standout ties for when European competition resumes in February include Galatasaray versus Valencia, Olympiacos against Dynamo Kiev, Rennes versus Real Betis and Sporting CP against Villarreal.