Memphis Depay is expected to be out for the rest of the season due to a serious knee injury, says Lyon sporting director Juninho.
Depay was substituted at half-time during Sunday's Ligue 1 defeat at home to Rennes, having initially been hurt in a tussle with Hamari Traore.
The forward sustained a suspected anterior cruciate ligament (ACL) injury to his left knee that could rule him out of action for several months.
Depay now faces a battle to return in time to feature for Netherlands at Euro 2020.
"We expect Memphis' injury to be quite serious," Juninho told OL TV .
"We expect it to keep him out for the rest of the season. He's our captain and I'm sad for him."
Depay's injury came after they had also lost Jeff Reine-Adelaide to a suspected meniscus problem, with reports suggesting he could be out for around four months.
The former Manchester United man has scored nine goals and assisted a further two in 13 Ligue 1 appearances this season, as well as netting five times in five Champions League games.
Rennes moved up to fourth in the Ligue 1 table thanks to a 1-0 win earned by a late goal scored by 17-year-old Eduardo Camavinga, with Lyon sitting eighth after 18 games.
Lyon coach Rudi Garcia said: "I'm not happy with the results or the performances. The evening is made worse by the fact that we lost Reine-Adelaide and Depay to injury."
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