Arsenal defenders Pablo Mari, Calum Chambers and midfielder Albert Sambi Lokonga were ruled out for Tuesday's League Cup quarterfinal at home to Sunderland after testing positive for COVID-19, the Premier League club said before kickoff.
Midfielder Ainsley Maitland-Niles was absent due to illness not related to COVID-19, the club added.
The Premier League said on Monday that a record 90 new cases of COVID-19 were detected among players and staff in the past week, as clubs decided to press ahead with the busy festive fixture list despite the escalating crisis.
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