Manchester City and Liverpool enter the Premier League home straight this weekend as Ole Gunnar Solskjaer takes his position in the Manchester United dugout for the first time as permanent boss.
With the international break over, City has eight games to retain its title but should it slip up, Liverpool is poised to pounce and become English champion for the first time since 1990 by winning its seven matches to come.
Pep Guardiola's City, trailing Liverpool by two points, can crank up the pressure on Jurgen Klopp's side by winning at Championship-bound Fulham on Saturday.
Liverpool has the far harder task of hosting Tottenham on Sunday but know that a win will be a huge step towards the title with a relatively kind fixture list to come, barring a home game against Chelsea.
“A season is like that, you constantly prepare a basis for the final weeks,” Klopp told Liverpool's official website.
“We are now in the final weeks and there will be no interruption anymore, there will only be game after game after game and they all are very, very important.”
Klopp has no injury concerns and plenty of reasons for optimism with Spurs mired in a slump and in danger of crashing out of the top four.
Mauricio Pochettino's men have taken just one point from their last four league games and could see their three-point cushion over fifth-placed Manchester United cancelled out by the time they kick-off at Anfield.
Tottenham's slide means Arsenal, Manchester United and Chelsea are involved in a four-way battle for the two Champions League places behind Liverpool and City.
Unai Emery's Arsenal are the form team in that group and go into their match at home to Newcastle on Monday buoyed by their win against Manchester Untied before the international break.
“In these next eight matches, we need to play with a lot of personality like we did against Manchester United,” Emery told Arsenal's website.
“We know it's going to be difficult because we are surrounded by other big teams but I think we are working very well and we are taking confidence to have chances in the last matches.”
United will be looking for a bounce after Solskjaer was appointed on a full-time basis on Thursday.
It takes on Watford at home on Saturday licking its wounds after defeat to Arsenal was followed by an FA Cup exit to Wolves, which has taken the shine off the Norwegian's flying start to life at Old Trafford.
“We are now in a great position to get into the Champions League but that is not decided until May 12 (the final day of the season) probably,” Solskjaer said.
“Eight games to go and two, so a quarter of what is left, against two fantastically improved teams in Watford and Wolves, best of the rest at the moment, so our focus and mine is on those two games,” he added.
Chelsea has stumbled in recent weeks with manager Maurizio Sarri facing multiple problems including a misfiring attack and pedestrian midfield.
Sarri hasn't considered teenage winger Callum Hudson-Odoi ready for a Premier League start by Sarri, but made his full debut for England against Montenegro earlier this week to pile pressure on the Italian to unleash him when Chelsea visit Cardiff on Sunday.
- Relegation scrap -
Another Chelsea slip up, though, could also have serious ramifications at the bottom of the table.
Cardiff is third from bottom, two points behind Burnley and Southampton with Brighton, Crystal Palace and Newcastle all within seven points of the drop zone.
Brighton and Southampton have a huge chance to gain some breathing space when they face off at the Amex on Saturday.
Huddersfield, rooted to the bottom 16 points from safety, appear doomed while Fulham also look headed for the drop unless it can shock City and eat into the 13-point gap that separates it from survival.
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