Inter Milan defender Danilo D'Ambrosio suffered a knee ligament injury in Wednesday's 2-1 Serie A loss at Sampdoria, the club said on Thursday.
Italy's Sky Sport said the 32-year-old full back could be out of action for four to five weeks.
D'Ambrosio left the field shortly before the end of the game after a collision with Sampdoria midfielder Mehdi Leris, having come on to replace Milan Skriniar in the 81st minute.
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"The tests revealed that the Italian has strained the medial collateral ligament of his left knee. His condition will be reassessed next week," Inter said in a statement.
The Italy international will miss Sunday's Serie A match at AS Roma and Wednesday's Coppa Italia game away to Fiorentina.
Inter is second in the standings on 36 points from 16 games, a point behind AC Milan and three points ahead of Roma.
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