Sadio Mane scored as Senegal won and his Liverpool teammate Naby Keita created a goal as Guinea drew when the 2022 World Cup group qualifying in Africa finally kicked off on Wednesday after three coronavirus-induced postponements.
Mane netted through a close-range shot on 56 minutes, and Paris Saint-Germain defender Abdou Diallo scored a similar goal nine minutes from time as Senegal beat Togo 2-0 in Thies.
Keita set up Francois Kamano, who gave Guinea a seventh-minute lead over Guinea-Bissau in neutral Nouakchott that was surrendered just after half-time when Joseph Mendes struck to earn a 1-1 draw.
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Unlike Mane and Keita, who played as their countries are not on the United Kingdom Covid-19 travel 'red list', star Liverpool forward Mohamed Salah could not turn out for Egypt against Angola in Cairo.
Two-time African Footballer of the Year Salah faced 10 days' quarantine on his return from red-listed Egypt, potentially missing four matches, had he travelled.
In his absence, record seven-time African champion Egypt won 1-0 in Group F, with Mohamed 'Afsha' Magdy converting a fifth-minute penalty kick.
Pierre-Emerick Aubameyang was given a boost as he captained Gabon to a 2-1 loss in Libya despite being yellow-carded, as Sanad al Ouarfali snatched an 89th-minute winner.
Aubameyang, who also leads Arsenal, suffered the humiliation of being substituted in a 5-0 English Premier League rout at Manchester City last Saturday.
Victory for Libya, who levelled through Ali Salama before half-time after Andre Poko put Gabon ahead, took the team to the top of Group F ahead of Egypt on goals scored.
Southampton midfielder Moussa Djenepo helped Mali edge Rwanda 1-0 in Moroccan coastal city Agadir, with Adama Traore the first-half match-winner.
- Guinea slips up -
Senegal is seeking to reach successive World Cup tournaments for the first time after its last attempt to do so came unstuck when it lost out to shock 2006 qualifier Togo.
Boasting a formidable 'spine' of Chelsea goalkeeper Edouard Mendy, Napoli centre-back Kalidou Koulibaly, PSG midfielder Idrissa Gueye and Mane, Senegal ensured Togo would not embarrass it again.
Senegal tops Group H with Namibia and Congo Brazzaville, the other contenders for one place in the final qualifying round, playing in South Africa on Thursday.
Namibia, along with Burkina Faso, Central African Republic, Djibouti, Guinea-Bissau, Malawi, Mali and Niger, has to play at neutral venues because it lacks international-standard stadiums.
Guinea, expected to pose the biggest threat to Group I favourite Morocco, will be disappointed that it failed to take full advantage of Guinea-Bissau having to move a home fixture to Mauritania.
Morocco hosts Sudan on Thursday with Bosnian coach Vahid Halilhodzic under pressure as he faces the sack if his team does not qualify for the World Cup in Qatar.
To secure a place at the 32-nation finals, five-time qualifiers Morocco must not only finish first but also win a two-leg play-off against another group winner next March.
Nigeria meets Liberia on Friday, knowing victory in Lagos will take it to the top of Group C after its other rivals, the Central African Republic and Cape Verde, drew 1-1 in rain-lashed Cameroonian city Douala.
Julio Tavares gave Cape Verde a half-time lead with a half-volley off a cross, and Tresor Toropite punished a fumble by goalkeeper Josimar 'Vozinha' Dias to equalise on 53 minutes.
On Thursday, Cup of Nations title-holder Algeria takes an African record 27-match unbeaten run into a home fixture against Djibouti, a tiny Horn of Africa country 152 places lower in the world rankings.
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