The biggest teams remaining in the FA Cup were kept apart in the draw for the fifth round on Monday.
Manchester City must travel to second-tier Bristol City while Manchester United was given another home match against West Ham, which beat third-tier Derby 2-0 a few hours after the draw.
Tottenham might have the most interesting match after being drawn against either second-tier Sheffield United or fifth-tier Wrexham, which is owned by Hollywood stars Ryan Reynolds and Rob McElhenney.
Wrexham was the lowest-ranked team remaining after holding Sheffield United to 3-3 on Sunday, setting up a replay next week.
Brighton, which eliminated defending champion Liverpool on Sunday, will travel to second-tier Stoke.
Eleven Premier League teams have already been ousted.
Fifth-round draw (matches take place week beginning Feb. 27):
- Southampton vs. Luton or Grimsby
- Leicester vs. Blackburn or Birmingham
- Stoke vs. Brighton
- Wrexham or Sheffield United vs. Tottenham
- Fulham or Sunderland vs. Leeds
- Bristol City vs. Manchester City
- Manchester United vs. West Ham
- Ipswich or Burnley vs. Sheffield Wednesday or Fleetwood
Follow all January deadline day stories here:
- Transfer deadline day: All you need to know about the January 2023 winter window
- Transfer Market Deadline Day: Players expected to sign on January 31
- Premier League Transfer news live: Full list of January 2023 signings
- La Liga winter transfer window: Complete list of ins and outs of players in January 2023
- January transfer window: Biggest winter signings which flopped at their new clubs
- Deadline day transfers: Suarez to Bruno, most impactful signings in the January winter window
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