Barcelona will host Real Madrid in the first Clasico of the season on October 26, with La Liga confirming it will be an early kick-off at Camp Nou.
Defending champion Barcelona beat Villarreal at home this week to move up to fourth in the table, but Madrid could go top with a win at home to Osasuna on Wednesday.
In the last Clasico, played at Camp Nou in March, Ivan Rakitic scored a delightful winner in a 1-0 victory to send Barca 10 points clear at the summit.
Captains Lionel Messi and Sergio Ramos were also involved in a flashpoint during a fiery clash, but Barca's talisman was withdrawn at half-time against Villarreal with a groin problem.
That was Messi's first start of the 2019-20 season after a calf injury sidelined him in the early weeks of the campaign.
Kick-off for the Clasico has been set for 13:00 CET (12:00 BST).