Borussia Dortmund suffered a major blow on Friday when Jadon Sancho, Raphael Guerreiro and Giovanni Reyna were ruled out of Saturday's Bundesliga game at champions Bayern Munich, the club said on Twitter.
Winger Sancho and midfielder Guerreiro had been taken off with minor muscle injuries in their midweek German Cup quarter-final win and have not fully recovered yet.
It was not clear why American teenager Reyna had not joined the squad on the trip to Munich.
Sancho's absence is especially painful as the in-form England international has been sensational in 2021, scoring eight goals in all competitions while setting up another seven.
Sancho was also on target in his side's 1-0 win over Borussia Moenchengladbach on Tuesday that sent them into the German Cup last four before being taken off.
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Dortmund has climbed back up to fifth place in the Bundesliga on 39 points having won its last two league games.
It is three points behind fourth-placed Eintracht Frankfurt, with the top four finishers qualifying for next season's Champions League.
Bayern is top on 52, two ahead of RB Leipzig.
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