Bayern Munich will hope to bounce back from a frustrating weekend in the Bundesliga as Robert Lewandowski targets a Champions League milestone against Benfica.
The German giant is not the only top side looking for a response, with free-scoring Manchester City facing Lyon, which defeated Pep Guardiola's men earlier in this campaign.
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City's group rival Hoffenheim is on a peculiar streak as it continues to make strides in European football, while Cristiano Ronaldo has a record in his sights for Juventus.
We bring you details of all of the above and more in the Opta numbers ahead of Tuesday's Champions League action.
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AEK Athens vs Ajax
3 - Ajax has won all three of the sides' previous meetings by an aggregate score of 7-1.
4 - AEK is one of just two teams to have lost all four of its Champions League games this season (along with Lokomotiv Moscow). It has never lost five in a row in the competition.
Bayern Munich vs Benfica
9 - Bayern has never lost to Benfica (W6 D3), winning 2-0 in Lisbon in the reverse fixture.
49 - Robert Lewandowski has scored 49 goals in 76 Champions League games. Only six players have ever reached 50 in the competition, while the Polish striker will be the third quickest to reach the milestone if he scores in this game.
Lyon vs Manchester City
1 - Lyon has only lost one of its 10 home European games against English sides (W3 D6), with that defeat coming against Arsenal in February 2001 (0-1).
12 - City is the highest scorers in this season's Champions League, netting 12 goals in its four games so far.
Hoffenheim vs Shakhtar Donetsk
12 - Hoffenheim has both scored and conceded in all 12 of its games played in European competitions.
14 - Shakhtar has not kept a clean sheet in any of its last 14 Champions League games, conceding a total of 30 goals in that run.
CSKA Moscow vs Viktoria Plzen
14 - Plzen has conceded more goals than any other side in the Champions League this season (14).
24 - CSKA has the youngest average starting XI in the Champions League so far this season (24y 20d), while Plzen has the oldest (29y 309d).
Roma vs Real Madrid
2 - Real Madrid has lost two of its last four away Champions League group stage games – more than it had lost in its previous 26 such games (W18 D7 L1).
13 - Since the start of last season, only Ronaldo (16) has scored more Champions League goals than Roma's Edin Dzeko (13).
Juventus vs Valencia
- Juventus lost its last home match against Manchester United - it has never lost consecutive home games in all European competitions in its history.
32 - Ronaldo has scored against 32 different opponents in the Champions League. If he scores against Valencia, he will equal Raul's competition record of having scored against 33 different teams.
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