Lionel Messi will hope for another successful clash with English opposition when Barcelona takes on Tottenham at Wembley on Wednesday.
That match is among several potentially thrilling Champions League fixtures, with Napoli hosting Liverpool, while Borussia Dortmund, with a poor home record, welcomes Monaco to Germany.
Atletico Madrid, Inter and Galatasaray will all hope to make it two wins from two, but Paris Saint-Germain is among the clubs looking to bounce back from an opening defeat.
Below, we look at the key Opta numbers from each fixture.
READ: Things don't go wrong in a week – Robben calm amid Bayern struggles
Atletico Madrid vs Club Brugge
15 - Antoine Griezmann has been directly involved in 15 of Atletico's last 17 Champions League goals scored at home (11 goals, 4 assists).
7 - Club Brugge has lost each of its last seven games in the Champions League, conceding 15 goals and scoring just twice.
Borussia Dortmund vs Monaco
4 - Dortmund is winless in its last four Champions League games at Signal Iduna Park (D1 L3), its worst ever run in the competition on home soil.
9 - Monaco is looking for its first win in the Champions League since the quarterfinal stage of the 2016-17 tournament, when it won both legs against Dortmund. Since those two victories, the French side has gone nine games without a win in the competition (D2 L7).
ALSO READ: Klopp urges Salah to stay 'relaxed'
Tottenham vs Barcelona
3 - Tottenham won all three of its home games in last season's Champions League group stage, scoring exactly three goals in each match.
20 - Lionel Messi has scored more goals (20) and provided more assists (6) against English clubs in the Champions League than against sides from any other nation.
PSV vs Inter
9 - PSV is winless in its last nine games in the Champions League (D4 L5), its longest such run in competition history.
8 - Inter has never lost to Dutch opposition in the Champions League in eight previous matches (W6 D2), the most it has faced teams from a single nation without defeat in the competition.
ALSO READ: We can't live in the past – Nacho tells Madrid to move on from Ronaldo
Paris Saint-Germain v Red Star Belgrade
17 - PSG has scored in each of its last 17 Champions League games; only Real Madrid is on a longer current scoring streak in the competition (29).
4 - Red Star has kept a clean sheet in each of its last four European group stage matches, although it has only scored once in that period.
Napoli vs Liverpool
4 - Napoli coach Carlo Ancelotti has never lost in the Champions League in four previous matches against Liverpool (W3 D1). However, that one draw was in the 2005 final, when the Reds came from 3-0 down at half-time to Ancelotti's AC Milan side to draw 3-3 before triumphing on penalties to win its fifth title.
20 - Liverpool lost just one of its six away games in the Champions League last season (W3 D2 L1), netting an impressive 20 goals - the only other team to have scored as many away goals in a single Champions League campaign was Real Madrid in 2013-14 (also 20).
ALSO READ: Valencia and Man United 100 per cent behind Mourinho
Lokomotiv Moscow vs Schalke
5 - Lokomotiv has lost each of its last five games against German opponents in European competition by an aggregate score of 13-2.
7 - Schalke is unbeaten in its last seven European matches at Veltins-Arena (W4 D3), scoring in each of those contests (13 goals in total).
Porto vs Galatasaray
2 - Porto defender Chancel Mbemba scored twice for former club Anderlecht in his last home Champions League appearance against Galatasaray back in November 2014.
11 - Galatasaray is winless in its last 11 Champions League games played away from home (D2 L9), conceding two or more goals in 10 of those matches (28 goals conceded).
Latest on Sportstar
- NBA Finals: Nikola Jokic, Nuggets cruise to win over Heat in Game 1 win
- FIR by wrestlers reveal traumatic experiences of sexual harassment by WFI chief Brij Bhushan Sharan Singh
- Heat 93-104 Nuggets Highlights, NBA Finals Game 1: Jokic, Murray shine as Denver takes lead
- Zverev makes winning return to French Open court of pain
- Stuttgart hammers 10-man Hamburg to take relegation playoff advantage