Juventus striker Mario Mandzukic has been ruled out of Tuesday's Champions League clash with Manchester United.
The Croatian suffered a sprained left ankle during training on Monday and has therefore been left out of the 20-man squad travelling to England.
The Serie A champion is otherwise mostly at full strength, with Emre Can the only other major absentee as he recovers from a thyroid problem.
Juve heads into the match at Old Trafford as leader of Group H, having claimed six points from a possible six this season. United is two points further back in second place.
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