Diego Forlan parted ways with Penarol on Monday after coaching the Uruguayan club for just 11 games, the former Manchester United and Atletico Madrid player said.
Forlan's team lost 2-0 at home to Wanderers on Sunday, their second defeat in four games.
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“Its time to leave Penarol,” he tweeted. “I have no complaints, thats football.”
The Montevideo club currently languishes in seventh place in the 16-team first division, six games after the league restarted following a five-month hiatus caused by the coronavirus pandemic.
It has won only four times since Forlan, a former Penarol and Uruguay striker, was appointed to his first managerial post last December.