Ashley Young has challenged Manchester United to storm to the finish line in the race to make the Premier League's top four, while Liverpool aim to take another step towards the Champions League.
With leader Chelsea and second placed Tottenham clashing in the FA Cup semifinals, the fight for Premier League supremacy is on hold until next week, but there is still plenty at stake in this weekend's fixtures.
Significantly, the other FA Cup semifinal features Arsenal and Manchester City and their leave of absence in the league means United has a golden opportunity to close the gap on the top four.
Jose Mourinho's fifth placed side breathed new life into their Champions League push with an impressive 2-0 victory over Chelsea last weekend and a win at Burnley on Sunday would leave them only one point behind fourth placed City.
Despite a series of spluttering performances at Old Trafford, Mourinho's men are unbeaten in their last 22 league games and United winger Young is confident a return to Europe's elite club competition after a one-year absence is well within their reach.
It can also reach that goal by winning the Europa League after making the semifinals on Thursday.
"I don't think a lot of people saw that scoreline against Chelsea coming or the type of game to be honest. We did," Young said.
"We have belief in ourselves. I have confidence in every single player. There is great competition in the squad. A lot has been said about how we want to finish fourth but I am that kind of person who wants to achieve more than that. I want to finish higher than that."
Liverpool is one of the teams United hope to catch, but its bitter rivals show no signs of slipping despite a growing injury list.
Fuelled by the superb form of Philippe Coutinho and Roberto Firmino, Jurgen Klopp's third placed side has won five times during a seven-match unbeaten run.
A victory over resurgent Crystal Palace at Anfield on Sunday would allow Liverpool to retain at least a six-point lead over fifth place.
It would also improve its chances of finishing in the top three, which brings qualification for the Champions League group stage, instead of the play-off early next season that awaits the team in fourth.
Resilient
As well as Coutinho and Firmino have played, Liverpool has also been indebted to Belgian goalkeeper Simon Mignolet, who kept his first clean sheet in almost two months in last weekend's 1-0 win at West Bromwich Albion.
"The last few performances against these teams like Burnley, Stoke and West Brom, we need to learn from that," Mignolet said.
"To be resilient, and to grind a result out, that's what we did, and I think everybody is pleased with that."
At the other end of the table, there will be plenty of nerve-jangling moments as Middlesbrough, Hull, Swansea and Bournemouth battle to avoid relegation.
Second bottom Middlesbrough is six points from safety and without a win in 16 games as they head to Bournemouth, who is seven points above the bottom three.
"We have to keep believing and keep the chin up. This is the toughest league there is, but we will keep grafting," Middlesbrough midfielder Adam Clayton said.
"The gap hasn't been getting any bigger, but now we are getting to the stage where we need to win. If we don't, it will be goodnight."
Time is also running out for third bottom Swansea, who host Stoke on Saturday, after five defeats in their last six matches left them two points from safety.
Fernando Llorente, Swansea's leading scorer, said: "We have done well at the Liberty Stadium and we have to do that again now.
"The game against Stoke is a massive match and we have to win."
Hull, two points above Swansea but beaten in their last two games, would do its survival hopes a power of good if it beats Watford at the KCOM Stadium.
Fixtures (1400 GMT unless stated)
Saturday
Bournemouth v Middlesbrough, Hull v Watford, Swansea v Stoke, West Ham v Everton
Sunday
Burnley v Manchester United (1315 GMT), Liverpool v Crystal Palace (1530 GMT)
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