Germany will be without midfielder Sami Khedira for Friday's World Cup qualifier against Czech Republic.
The Juventus man is believed to have suffered a knee injury and will not be risked for the meeting in Prague.
Germany hopes to have the 30-year-old available for Monday's game against Norway, so he will remain with the squad.
The news comes after winger Serge Gnabry was forced to withdraw from Joachim Low's plans as a result of an ankle ligament problem.
The 22-year-old, on loan at Hoffenheim from Bayern Munich, will not be fit for either match and returned home from the team hotel in Stuttgart on Tuesday.
Germany sits top of Group C with four games left to play, having won each of its six encounters so far.