Manchester City will look to do a rare Premier League double over Chelsea this weekend as they continue to march towards the title.
Behind them, Liverpool and Manchester United face two sides they have enjoyed plenty of success against in the past.
The battle to stay in the division goes on with a six-pointer at the St Mary's Stadium between Southampton and Stoke City.
BURNLEY VS EVERTON
After a sensational first half of the season Burnley are enduring their longest Premier League run without a win – 11 games.
Sean Dyche's men welcome Everton to Turf Moor having taken six points from a potential 33, but remarkably they remain in seventh place in the table.
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Everton's away form will give the Clarets hope, the visitors having won the fewest percentage of points on their travels, just 24 per cent, which equates to eight from 34.
LEICESTER CITY VS BOURNEMOUTH
Leicester City will hope for a Premier League first on Saturday as they continue to hunt down a top-seven place, the Foxes having never beaten Bournemouth in the competition.
Goals may be limited, however, with only five goals in the five previous meetings – Jamie Vardy grabbing both of Leicester's.
No side have gained more points from losing positions this season than Bournemouth (13), a fighting spirit that was in full evidence last weekend when they came from 2-0 down to draw with Newcastle United.
SOUTHAMPTON VS STOKE CITY
Stoke City will hope to lift themselves out of the bottom three against Southampton on Saturday, the Potters having won both of their last two visits to St Mary's Stadium.
Xherdan Shaqiri is the shining light in Paul Lambert's team at present, although Peter Crouch could be the man to turn to after scoring 12 goals against sides he once played for – including four against the Saints for Stoke.
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Southampton come into the game with just one win in their last 15 league matches, and they are winless in seven on home soil – leaving them just one point ahead of this weekend's visitors.
SWANSEA CITY VS WEST HAM
The Swansea City revival juddered to a halt in Brighton last weekend, but Carlos Carvalhal will hope home comforts can get them back on track.
Swansea have won their last three matches at the Liberty Stadium, a fourth would be a rare treat, having not done it since May 2016.
West Ham will arrive in south Wales full of confidence, though, given they are four games unbeaten away to Swansea – including a 4-1 triumph last season.
TOTTENHAM VS HUDDERSFIELD
Wembley Stadium is a happy hunting ground for Huddersfield Town, but with Harry Kane in lethal form the Terriers face a tough task extending their four-game unbeaten run at the home of English football.
Spurs are currently enjoying the Premier League's longest unbeaten run (10 games), their last defeat coming at Manchester City in December.
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Kane moved onto 24 league goals against Crystal Palace, and should he make it 25 on Saturday he will be the third player to have scored 25 or more goals in three consecutive campaigns – after Alan Shearer and Thierry Henry.
WATFORD VS WEST BROM
The signs do not look good for West Brom after losing their last four matches, the Baggies rooted to the foot of the table, seven points from safety.
Defeat against Watford could see the end of Alan Pardew, and he will not be cheered to learn Albion have not won at Vicarage Road since 2007.
One positive is that Watford have already lost to two sides in 20th position this season – Crystal Palace and Swansea City – but the Hornets are on a two-game winning streak at home.
LIVERPOOL VS NEWCASTLE UNITED
Liverpool's chase for second place in the Premier League continues with the visit of Newcastle United on Saturday, evoking memories of goal-laden clashes of years gone by.
The Reds have scored more goals against Newcastle than they have against any other side in the competition (89), and are unbeaten in 21 home league matches against the Magpies – a run that stretches back to 1994.
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After throwing a two-goal lead away last weekend, Newcastle are still in the battle to avoid relegation, sitting two points above the bottom three.
Mohamed Salah – 23 goals this season - will be the main threat for Rafa Benitez, the Spaniard returning having drawn all three of his previous visits to Anfield.
BRIGHTON AND HOVE ALBION VS ARSENAL
Arsenal need a morale-boosting win at the Amex Stadium to keep their top-four hopes alive, and they will be buoyed by the fact they have won on both visits to the venue.
Brighton and Hove Albion found their scoring boots last weekend, though, and will look to Glenn Murray to record a third win in a row at home.
Murray has scored 10 times this season, including five in his last five home games.
MANCHESTER CITY VS CHELSEA
The Manchester City juggernaut rolls on with a first piece of silverware already in the trophy cabinet after their EFL Cup triumph.
Pep Guardiola's men are looking to do the double over Chelsea for the third time on Sunday, but the Blues won this fixture 3-1 last season.
Chelsea have, however, lost three of their last four games, including two on their travels – they have not lost three away matches in a row since March 2013.
Sergio Aguero has scored five goals in his last four league encounters with Chelsea, while Eden Hazard has had a hand in eight against City in seven games.
CRYSTAL PALACE VS MANCHESTER UNITED
Crystal Palace have not won any of their 17 Premier League meetings with Manchester United – the most a team has played another without a single victory.
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However, the last time Palace played on a Monday they beat Arsenal 3-0 in April.
Paul Pogba has scored in both of his league games versus Palace - the Eagles are the only team the France international has scored both home and away against in the competition.
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